Digoxin
Indication: Atrial fibrillation and congestive heart failure in older adults
Interactive elderly digoxin population pharmacokinetic simulator exploring dose, renal function, body weight, heart failure, calcium-channel blockers, and spironolactone.
Drug Overview
Clinical Context
- Molecular Target
- Na+/K+-ATPase
- Drug Class
- Cardiac glycoside
- Therapeutic Area
- Cardiology
- Indication
- Atrial fibrillation and congestive heart failure in older adults
- Route of Administration
- Oral
Model Information
- Model Type
- One-compartment population PK
This simulator was built from published pharmacometric literature using PKPDBuilder's AI-powered model extraction pipeline.
Pharmacokinetic Parameters
Additional Parameters
| Parameter | Value |
|---|---|
| KA h-1 | 3.85 |
| V equation | 420*1.2^(TBW/62)*0.857^CHF |
| CL equation | 8.9*0.651^(SCr/111)*(1+0.001*(TBW-62))*0.769^CCB*0.813^SPI*0.881^CHF |
| source model | Chen et al. 2013 |
| therapeutic window ng m L | [0.5,0.8] |
Parameters sourced from published population pharmacokinetic models. Values represent typical population estimates; individual patient parameters may vary.
About This Simulator
This interactive pharmacokinetic simulator for Digoxin allows you to explore concentration-time profiles under different dosing scenarios. The underlying One-compartment population PK model characterizes the pharmacokinetics of this cardiac glycoside following oral administration.
Use the simulator to visualize key exposure metrics including AUC (area under the curve), Cmax (peak concentration), and Ctrough (trough concentration).
Built with PKPDBuilder — an AI-powered platform that transforms published pharmacometric literature into interactive, deployable Shiny applications. No coding required.
Frequently Asked Questions
What is the Digoxin PK simulator?
This is a free, interactive pharmacokinetic simulator for Digoxin used in Atrial fibrillation and congestive heart failure in older adults. It allows researchers, pharmacologists, and students to explore concentration-time profiles, dosing regimens, and exposure metrics based on published population PK models.
What drug class does Digoxin belong to?
Digoxin is classified as a Cardiac glycoside that targets Na+/K+-ATPase. It is used in the Cardiology therapeutic area.
What route of administration does this model simulate?
This simulator models Oral administration of Digoxin. The pharmacokinetic parameters (absorption rate, bioavailability, volume of distribution) are specific to this route.
What type of PK model is used?
This simulator uses a One-compartment population PK model. This model characterizes the time-course of drug concentrations following dosing.
Is this simulator free to use?
Yes, all PKPDBuilder simulators are completely free. They are built from published pharmacokinetic literature and are intended for research and educational purposes. No login is required to run simulations.
Can I use this for clinical dosing decisions?
No. This simulator is for research and educational purposes only. It should not be used for clinical decision-making or patient dosing. Always consult the prescribing information and clinical pharmacology guidelines for therapeutic drug use.
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Ready to Simulate?
Launch the Digoxin simulator to explore dosing scenarios and pharmacokinetic profiles interactively.
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⚠️ Disclaimer
This simulator is for research and educational purposes only. It is not intended for clinical decision-making, patient dosing, or therapeutic drug monitoring. Pharmacokinetic parameters are derived from published literature and represent population-level estimates. Individual patient pharmacokinetics may differ significantly. Always consult approved prescribing information and qualified healthcare professionals for clinical decisions.
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