Digoxin PK Simulator
Indication: Heart Failure / Atrial Fibrillation
Population PK simulator for digoxin. Therapeutic drug monitoring and renal function adjustment.
Drug Overview
Clinical Context
- Molecular Target
- Na/K-ATPase
- Drug Class
- Small Molecule
- Therapeutic Area
- Cardiology
- Indication
- Heart Failure / Atrial Fibrillation
- Route of Administration
- Oral
Model Information
- Model Type
- PopPK
This simulator was built from published pharmacometric literature using PKPDBuilder's AI-powered model extraction pipeline.
Pharmacokinetic Parameters
PK Parameters
| Parameter | Value |
|---|---|
| Q | 34 L/h |
| CL | 7-8 L/h (normal renal) |
| Vc | 38 L |
| Vp | 420 L |
| ka | 1.0-1.5 h⁻¹ |
| Vss | ~500 L |
| t half | 36-48 h |
| bioavailability | 0.63 (tablet), 0.75 (elixir) |
| protein binding | 25% |
Additional Parameters
| Parameter | Value |
|---|---|
| IIV CL | 30% CV |
| CL renal | ~5.4 L/h |
| therapeutic range | 0.5-2.0 ng/mL |
Parameters sourced from published population pharmacokinetic models. Values represent typical population estimates; individual patient parameters may vary.
About This Simulator
This interactive pharmacokinetic simulator for Digoxin allows you to explore concentration-time profiles under different dosing scenarios. The underlying PopPK model characterizes the pharmacokinetics of this small molecule following oral administration.
Use the simulator to visualize key exposure metrics including AUC (area under the curve), Cmax (peak concentration), and Ctrough (trough concentration).
Built with PKPDBuilder — an AI-powered platform that transforms published pharmacometric literature into interactive, deployable Shiny applications. No coding required.
Frequently Asked Questions
What is the Digoxin PK simulator?
This is a free, interactive pharmacokinetic simulator for Digoxin used in Heart Failure / Atrial Fibrillation. It allows researchers, pharmacologists, and students to explore concentration-time profiles, dosing regimens, and exposure metrics based on published population PK models.
What drug class does Digoxin belong to?
Digoxin is classified as a Small Molecule that targets Na/K-ATPase. It is used in the Cardiology therapeutic area.
What route of administration does this model simulate?
This simulator models Oral administration of Digoxin. The pharmacokinetic parameters (absorption rate, bioavailability, volume of distribution) are specific to this route.
What type of PK model is used?
This simulator uses a PopPK model. Population PK models account for interindividual variability and covariate effects on drug exposure.
Is this simulator free to use?
Yes, all PKPDBuilder simulators are completely free. They are built from published pharmacokinetic literature and are intended for research and educational purposes. No login is required to run simulations.
Can I use this for clinical dosing decisions?
No. This simulator is for research and educational purposes only. It should not be used for clinical decision-making or patient dosing. Always consult the prescribing information and clinical pharmacology guidelines for therapeutic drug use.
What is the half-life of Digoxin?
Based on the published model parameters, the elimination half-life of Digoxin is approximately 36-48 h. Note that half-life can vary based on patient-specific factors such as body weight, organ function, and genetic polymorphisms.
What is the clearance of Digoxin?
The clearance (CL) of Digoxin is approximately 7-8 L/h (normal renal). Clearance represents the volume of plasma from which drug is completely removed per unit time and is a key determinant of drug exposure and steady-state concentrations.
Related Simulators
Xtandi (Enzalutamide) PK Simulator
Metastatic castration-resistant prostate cancer
Xarelto (Rivaroxaban) PK Simulator
Stroke prevention in atrial fibrillation
Vyndaqel (Tafamidis) PK Simulator
Transthyretin amyloid cardiomyopathy
Verzenio (Abemaciclib) PK Simulator
HR+/HER2- metastatic breast cancer
Trikafta (Elexacaftor/Tezacaftor/Ivacaftor) PK Simulator
Cystic fibrosis
Tagrisso (Osimertinib) PK Simulator
EGFR-mutated non-small cell lung cancer
Ready to Simulate?
Launch the Digoxin simulator to explore dosing scenarios and pharmacokinetic profiles interactively.
🚀 Launch SimulatorComments
⚠️ Disclaimer
This simulator is for research and educational purposes only. It is not intended for clinical decision-making, patient dosing, or therapeutic drug monitoring. Pharmacokinetic parameters are derived from published literature and represent population-level estimates. Individual patient pharmacokinetics may differ significantly. Always consult approved prescribing information and qualified healthcare professionals for clinical decisions.
Powered by PKPDBuilder.com • Free pharmacokinetic simulators for the scientific community