Ayyar mPBPK
Indication: Acute hepatic porphyria
Interactive givosiran PBPK-PD simulator based on Ayyar and Song 2024 with rat, monkey, and human scenarios for plasma PK, tissue distribution, RISC loading, and ALAS1 response.
Drug Overview
Clinical Context
- Molecular Target
- ALAS1
- Drug Class
- GalNAc-siRNA
- Therapeutic Area
- Rare disease
- Indication
- Acute hepatic porphyria
- Route of Administration
- SC, IV
Model Information
- Model Type
- Mechanistic translational PBPK-PD
This simulator was built from published pharmacometric literature using PKPDBuilder's AI-powered model extraction pipeline.
Pharmacokinetic Parameters
Additional Parameters
| Parameter | Value |
|---|---|
| f sc | 0.9 |
| kd n M | 27.7 |
| notes | Human tissue and PD outputs are exploratory mechanistic projections; human plasma PK is the directly validated clinical output. |
| koff h | 1.32 |
| species | ["rat","monkey","human"] |
| sc50 ng g | 6.1 |
| human ka h | 0.036 |
| human vc L | 2.8 |
| human kint h | 1.9 |
| risc total n M | 30 |
Parameters sourced from published population pharmacokinetic models. Values represent typical population estimates; individual patient parameters may vary.
About This Simulator
This interactive pharmacokinetic simulator for Ayyar mPBPK allows you to explore concentration-time profiles under different dosing scenarios. The underlying Mechanistic translational PBPK-PD model characterizes the pharmacokinetics of this galnac-sirna following sc, iv administration.
Use the simulator to visualize key exposure metrics including AUC (area under the curve), Cmax (peak concentration), and Ctrough (trough concentration). The pharmacodynamic component links drug exposure to therapeutic or safety endpoints.
Built with PKPDBuilder — an AI-powered platform that transforms published pharmacometric literature into interactive, deployable Shiny applications. No coding required.
Frequently Asked Questions
What is the Ayyar mPBPK PK simulator?
This is a free, interactive pharmacokinetic simulator for Ayyar mPBPK used in Acute hepatic porphyria. It allows researchers, pharmacologists, and students to explore concentration-time profiles, dosing regimens, and exposure metrics based on published population PK models.
What drug class does Ayyar mPBPK belong to?
Ayyar mPBPK is classified as a GalNAc-siRNA that targets ALAS1. It is used in the Rare disease therapeutic area.
What route of administration does this model simulate?
This simulator models SC, IV administration of Ayyar mPBPK. The pharmacokinetic parameters (absorption rate, bioavailability, volume of distribution) are specific to this route.
What type of PK model is used?
This simulator uses a Mechanistic translational PBPK-PD model. PBPK models use physiological parameters to predict drug distribution across tissues and organs.
Is this simulator free to use?
Yes, all PKPDBuilder simulators are completely free. They are built from published pharmacokinetic literature and are intended for research and educational purposes. No login is required to run simulations.
Can I use this for clinical dosing decisions?
No. This simulator is for research and educational purposes only. It should not be used for clinical decision-making or patient dosing. Always consult the prescribing information and clinical pharmacology guidelines for therapeutic drug use.
Ready to Simulate?
Launch the Ayyar mPBPK simulator to explore dosing scenarios and pharmacokinetic profiles interactively.
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⚠️ Disclaimer
This simulator is for research and educational purposes only. It is not intended for clinical decision-making, patient dosing, or therapeutic drug monitoring. Pharmacokinetic parameters are derived from published literature and represent population-level estimates. Individual patient pharmacokinetics may differ significantly. Always consult approved prescribing information and qualified healthcare professionals for clinical decisions.
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