Imatinib PK Simulator
Indication: CML / GIST
Population PK simulator for imatinib (Gleevec). Explore exposure-response and dose optimization in CML.
Drug Overview
Clinical Context
- Molecular Target
- BCR-ABL
- Drug Class
- Small Molecule
- Therapeutic Area
- Oncology
- Indication
- CML / GIST
- Route of Administration
- Oral
Model Information
- Model Type
- PopPK
This simulator was built from published pharmacometric literature using PKPDBuilder's AI-powered model extraction pipeline.
Pharmacokinetic Parameters
PK Parameters
| Parameter | Value |
|---|---|
| ka | 0.5-1.0 h⁻¹ |
| CL F | 12-15 L/h |
| Tmax | 2-4 h |
| Vc F | 220 L |
| t half | 18 h (parent), 40 h (metabolite) |
| bioavailability | 0.98 |
| protein binding | 95% (albumin + AGP) |
Additional Parameters
| Parameter | Value |
|---|---|
| dose | 400-800 mg QD |
| IIV CL | 40% CV |
| Cmin target | >1000 ng/mL (CML) |
Parameters sourced from published population pharmacokinetic models. Values represent typical population estimates; individual patient parameters may vary.
About This Simulator
This interactive pharmacokinetic simulator for Imatinib allows you to explore concentration-time profiles under different dosing scenarios. The underlying PopPK model characterizes the pharmacokinetics of this small molecule following oral administration.
Use the simulator to visualize key exposure metrics including AUC (area under the curve), Cmax (peak concentration), and Ctrough (trough concentration).
Built with PKPDBuilder — an AI-powered platform that transforms published pharmacometric literature into interactive, deployable Shiny applications. No coding required.
Frequently Asked Questions
What is the Imatinib PK simulator?
This is a free, interactive pharmacokinetic simulator for Imatinib used in CML / GIST. It allows researchers, pharmacologists, and students to explore concentration-time profiles, dosing regimens, and exposure metrics based on published population PK models.
What drug class does Imatinib belong to?
Imatinib is classified as a Small Molecule that targets BCR-ABL. It is used in the Oncology therapeutic area.
What route of administration does this model simulate?
This simulator models Oral administration of Imatinib. The pharmacokinetic parameters (absorption rate, bioavailability, volume of distribution) are specific to this route.
What type of PK model is used?
This simulator uses a PopPK model. Population PK models account for interindividual variability and covariate effects on drug exposure.
Is this simulator free to use?
Yes, all PKPDBuilder simulators are completely free. They are built from published pharmacokinetic literature and are intended for research and educational purposes. No login is required to run simulations.
Can I use this for clinical dosing decisions?
No. This simulator is for research and educational purposes only. It should not be used for clinical decision-making or patient dosing. Always consult the prescribing information and clinical pharmacology guidelines for therapeutic drug use.
What is the half-life of Imatinib?
Based on the published model parameters, the elimination half-life of Imatinib is approximately 18 h (parent), 40 h (metabolite). Note that half-life can vary based on patient-specific factors such as body weight, organ function, and genetic polymorphisms.
What is the clearance of Imatinib?
The clearance (CL) of Imatinib is approximately 12-15 L/h. Clearance represents the volume of plasma from which drug is completely removed per unit time and is a key determinant of drug exposure and steady-state concentrations.
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Ready to Simulate?
Launch the Imatinib simulator to explore dosing scenarios and pharmacokinetic profiles interactively.
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⚠️ Disclaimer
This simulator is for research and educational purposes only. It is not intended for clinical decision-making, patient dosing, or therapeutic drug monitoring. Pharmacokinetic parameters are derived from published literature and represent population-level estimates. Individual patient pharmacokinetics may differ significantly. Always consult approved prescribing information and qualified healthcare professionals for clinical decisions.
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