Tacro2
Indication: Allogeneic hematopoietic cell transplantation (allo-HCT)
Interactive two-compartment population PK simulator for oral tacrolimus in adult allogeneic hematopoietic cell transplant (allo-HCT) recipients. Includes CYP3A5 metabolizer phenotype and conditioning regimen intensity covariates. Based on Dunlap et al. (2025) Clin Pharmacokinet.
Drug Overview
Clinical Context
- Molecular Target
- Calcineurin
- Drug Class
- Calcineurin Inhibitor
- Therapeutic Area
- Transplant / Immunosuppression
- Indication
- Allogeneic hematopoietic cell transplantation (allo-HCT)
- Route of Administration
- Oral
Model Information
- Model Type
- PopPK (2-compartment)
- Reference
- Dunlap et al. (2025) Clin Pharmacokinet
This simulator was built from published pharmacometric literature using PKPDBuilder's AI-powered model extraction pipeline.
Pharmacokinetic Parameters
PK Parameters
| Parameter | Value |
|---|---|
| Q | 43 L/h |
| Ka | 0.50 h⁻¹ |
| V1 | 150 L |
| V2 | 1153 L |
| CL F | 23 L/h |
Parameters sourced from published population pharmacokinetic models. Values represent typical population estimates; individual patient parameters may vary.
About This Simulator
This interactive pharmacokinetic simulator for Tacro2 allows you to explore concentration-time profiles under different dosing scenarios. The underlying PopPK (2-compartment) model characterizes the pharmacokinetics of this calcineurin inhibitor following oral administration.
Use the simulator to visualize key exposure metrics including AUC (area under the curve), Cmax (peak concentration), and Ctrough (trough concentration).
Built with PKPDBuilder — an AI-powered platform that transforms published pharmacometric literature into interactive, deployable Shiny applications. No coding required.
Frequently Asked Questions
What is the Tacro2 PK simulator?
This is a free, interactive pharmacokinetic simulator for Tacro2 used in Allogeneic hematopoietic cell transplantation (allo-HCT). It allows researchers, pharmacologists, and students to explore concentration-time profiles, dosing regimens, and exposure metrics based on published population PK models.
What drug class does Tacro2 belong to?
Tacro2 is classified as a Calcineurin Inhibitor that targets Calcineurin. It is used in the Transplant / Immunosuppression therapeutic area.
What route of administration does this model simulate?
This simulator models Oral administration of Tacro2. The pharmacokinetic parameters (absorption rate, bioavailability, volume of distribution) are specific to this route.
What type of PK model is used?
This simulator uses a PopPK (2-compartment) model. Population PK models account for interindividual variability and covariate effects on drug exposure.
Is this simulator free to use?
Yes, all PKPDBuilder simulators are completely free. They are built from published pharmacokinetic literature and are intended for research and educational purposes. No login is required to run simulations.
Can I use this for clinical dosing decisions?
No. This simulator is for research and educational purposes only. It should not be used for clinical decision-making or patient dosing. Always consult the prescribing information and clinical pharmacology guidelines for therapeutic drug use.
What is the clearance of Tacro2?
The clearance (CL) of Tacro2 is approximately 23 L/h. Clearance represents the volume of plasma from which drug is completely removed per unit time and is a key determinant of drug exposure and steady-state concentrations.
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⚠️ Disclaimer
This simulator is for research and educational purposes only. It is not intended for clinical decision-making, patient dosing, or therapeutic drug monitoring. Pharmacokinetic parameters are derived from published literature and represent population-level estimates. Individual patient pharmacokinetics may differ significantly. Always consult approved prescribing information and qualified healthcare professionals for clinical decisions.
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