Open test
Indication: Prurigo nodularis and chronic pruritic conditions
Interactive vixarelimab PK simulator based on a 2-compartment TMDD/QSS population pharmacokinetic model reported by Tang et al. 2026 in healthy volunteers and patients with chronic pruritic conditions.
Drug Overview
Clinical Context
- Molecular Target
- OSMRβ
- Drug Class
- Monoclonal antibody
- Therapeutic Area
- Dermatology / Chronic pruritic disorders
- Indication
- Prurigo nodularis and chronic pruritic conditions
- Route of Administration
- SC and IV
Model Information
- Model Type
- 2-compartment TMDD PopPK
This simulator was built from published pharmacometric literature using PKPDBuilder's AI-powered model extraction pipeline.
About This Simulator
This interactive pharmacokinetic simulator for Open test allows you to explore concentration-time profiles under different dosing scenarios. The underlying 2-compartment TMDD PopPK model characterizes the pharmacokinetics of this monoclonal antibody following sc and iv administration.
Use the simulator to visualize key exposure metrics including AUC (area under the curve), Cmax (peak concentration), and Ctrough (trough concentration).
Built with PKPDBuilder — an AI-powered platform that transforms published pharmacometric literature into interactive, deployable Shiny applications. No coding required.
Frequently Asked Questions
What is the Open test PK simulator?
This is a free, interactive pharmacokinetic simulator for Open test used in Prurigo nodularis and chronic pruritic conditions. It allows researchers, pharmacologists, and students to explore concentration-time profiles, dosing regimens, and exposure metrics based on published population PK models.
What drug class does Open test belong to?
Open test is classified as a Monoclonal antibody that targets OSMRβ. It is used in the Dermatology / Chronic pruritic disorders therapeutic area.
What route of administration does this model simulate?
This simulator models SC and IV administration of Open test. The pharmacokinetic parameters (absorption rate, bioavailability, volume of distribution) are specific to this route.
What type of PK model is used?
This simulator uses a 2-compartment TMDD PopPK model. Population PK models account for interindividual variability and covariate effects on drug exposure.
Is this simulator free to use?
Yes, all PKPDBuilder simulators are completely free. They are built from published pharmacokinetic literature and are intended for research and educational purposes. No login is required to run simulations.
Can I use this for clinical dosing decisions?
No. This simulator is for research and educational purposes only. It should not be used for clinical decision-making or patient dosing. Always consult the prescribing information and clinical pharmacology guidelines for therapeutic drug use.
Related Simulators
Ready to Simulate?
Launch the Open test simulator to explore dosing scenarios and pharmacokinetic profiles interactively.
🚀 Launch SimulatorComments
⚠️ Disclaimer
This simulator is for research and educational purposes only. It is not intended for clinical decision-making, patient dosing, or therapeutic drug monitoring. Pharmacokinetic parameters are derived from published literature and represent population-level estimates. Individual patient pharmacokinetics may differ significantly. Always consult approved prescribing information and qualified healthcare professionals for clinical decisions.
Powered by PKPDBuilder.com • Free pharmacokinetic simulators for the scientific community