Pharmacokinetics Simulators by Therapeutic Area

Browse 183+ free interactive PK simulators organized by therapeutic area. Each area includes drug-specific models with dosing, covariate effects, and exposure metrics.

Oncology

48

Cancer pharmacotherapy including chemotherapy, targeted therapy, immunotherapy, and ADCs

ADC Effector FunctionDoxorubicinTrastuzumab (Herceptin) PBPK-TMDDPBPK-PD Topo1-Based ADC+44

Immunology

15

Immune-mediated diseases including rheumatoid arthritis, psoriasis, and atopic dermatitis

Enbrel (Etanercept)Orencia (Abatacept)Betamethasone MetaboliteBetamethasone NCA+11

Infectious Disease

12

Anti-infective agents including antibiotics, antivirals, and antifungals

Gentamicin TDMAntibiotic PD InteractionOxfendazole PopulationCiprofloxacin+8

Cardiology

10

Cardiovascular drugs including anticoagulants, antiarrhythmics, and lipid-lowering agents

Asundexian FXIa InhibitorDigoxinEliquis (Apixaban)Entresto (Sacubitril/Valsartan)+6

Endocrinology

8

Metabolic and endocrine drugs including GLP-1 agonists, SGLT2 inhibitors, and insulin

Mounjaro (Tirzepatide)Ozempic (Semaglutide)Rybelsus (Oral Semaglutide)Trulicity (Dulaglutide)+4

Transplant

5

Immunosuppressive agents for organ transplant rejection prophylaxis

Cyclosporine TDMTacrolimus TDMCyclosporineMycophenolate+1

Platform

5

General-purpose PK/PD modeling frameworks and tools

QSP PlatformPopPK FrameworkMinimal Antibody PBPKmAb PBPK (Shah-Betts)+1

Rare Disease

4

Orphan drugs for rare genetic and metabolic disorders

DonidalorsenmRNA-3927Givosiran ALAGivosiran

Neurology

4

Neurological drugs including anticonvulsants and disease-modifying therapies

Carbamazepine TDMPhenytoin TDMDACOcrevus (Ocrelizumab)

Cardiovascular

3

Pharmacokinetic simulators for Cardiovascular therapeutics

PopDigoxin TDMWarfarin

Metabolic

3

Metabolic disease drugs including diabetes, obesity, and lipid disorders

SemaglutideInsulinWeight-HbA1c-Glucose

Pulmonology

3

Respiratory and pulmonary disease therapeutics

TehopyllineTestOfev (Nintedanib)Trikafta (Elexacaftor/Tezacaftor/Ivacaftor)

Pain

2

Analgesics and pain management agents

AcetaminophenMorphine

Oncology / NSCLC

2

Cancer pharmacotherapy including chemotherapy, targeted therapy, immunotherapy, and ADCs

Patritumab Deruxtecan (HER3-DXd)poppk

Psychiatry

2

Psychotropic medications including antidepressants and antipsychotics

VortioxetineInvega Sustenna (Paliperidone Palmitate)

Infectious Disease / Critical Care

2

Anti-infective agents including antibiotics, antivirals, and antifungals

Cefepime "Jonckheere"Population

Hematology

2

Blood disorder treatments including hemophilia therapies

Hemlibra (Emicizumab)Concizumab

Ophthalmology

2

Ophthalmic drugs for retinal and macular diseases

Vabysmo (Faricimab)Eylea (Aflibercept)

Infectious Disease - Tuberculosis

2

Anti-infective agents including antibiotics, antivirals, and antifungals

Bedaquiline trialRifapentine

Type 2 Diabetes

2

Pharmacokinetic simulators for Type 2 Diabetes therapeutics

Efsubaglutide AlfaEmpagliflozin

Oncology (NSCLC)

1

Cancer pharmacotherapy including chemotherapy, targeted therapy, immunotherapy, and ADCs

RMC

Hypertension

1

Pharmacokinetic simulators for Hypertension therapeutics

Abc

Infectious Disease - Critical Care

1

Anti-infective agents including antibiotics, antivirals, and antifungals

Amikacine

Oncology / Ovarian Cancer

1

Cancer pharmacotherapy including chemotherapy, targeted therapy, immunotherapy, and ADCs

Mirvetuximab Soravtansine (ELAHERE)

Oncology / Breast Cancer

1

Cancer pharmacotherapy including chemotherapy, targeted therapy, immunotherapy, and ADCs

T-DXd (Enhertu) PBPK-PD ILD Risk

Psychiatry / Neurology

1

Neurological drugs including anticonvulsants and disease-modifying therapies

Tapering- Venlafaxine

Neurology / Epilepsy

1

Neurological drugs including anticonvulsants and disease-modifying therapies

OXZ_PopPK

Oncology — Acute Lymphoblastic Leukemia

1

Cancer pharmacotherapy including chemotherapy, targeted therapy, immunotherapy, and ADCs

MTXPK

Transthyretin Amyloidosis (ATTR)

1

Pharmacokinetic simulators for Transthyretin Amyloidosis (ATTR) therapeutics

Eplontersen

Hereditary Transthyretin Amyloidosis (hATTR)

1

Pharmacokinetic simulators for Hereditary Transthyretin Amyloidosis (hATTR) therapeutics

Inotersen

Infectious Disease / Transplant

1

Anti-infective agents including antibiotics, antivirals, and antifungals

Modèle Caldes

Transplantation / Infectious Disease

1

Anti-infective agents including antibiotics, antivirals, and antifungals

Modèle Chen

Transplant Medicine / Infectious Disease

1

Anti-infective agents including antibiotics, antivirals, and antifungals

Implémentation modèle Vezina

Anesthesia

1

Pharmacokinetic simulators for Anesthesia therapeutics

Midazolam

Pediatric Infectious Disease / Neonatology

1

Anti-infective agents including antibiotics, antivirals, and antifungals

Piperacilin

HIV Prevention

1

Pharmacokinetic simulators for HIV Prevention therapeutics

VRC07-523-LS

Transplant / Immunosuppression

1

Immunosuppressive agents for organ transplant rejection prophylaxis

Tacro2

Transplant Immunosuppression

1

Immunosuppressive agents for organ transplant rejection prophylaxis

model replication (Benkali_et al)

Transplantation / Nephrology

1

Immunosuppressive agents for organ transplant rejection prophylaxis

Tacrolimus

Hematology / Transplantation

1

Immunosuppressive agents for organ transplant rejection prophylaxis

Tacrolimus pop

Obstetrics / Maternal-Fetal Medicine

1

Pharmacokinetic simulators for Obstetrics / Maternal-Fetal Medicine therapeutics

NCA BET

Tuberculosis

1

Pharmacokinetic simulators for Tuberculosis therapeutics

Moxifloxacin Pediatric

Obesity / Weight Management

1

Pharmacokinetic simulators for Obesity / Weight Management therapeutics

semaglutide

General

1

Pharmacokinetic simulators for General therapeutics

PK

Immunology / Antiparasitic / Oncology (adjuvant)

1

Cancer pharmacotherapy including chemotherapy, targeted therapy, immunotherapy, and ADCs

test

HIV / Infectious Disease

1

Anti-infective agents including antibiotics, antivirals, and antifungals

DTg

Cardiology / Nephrology

1

Cardiovascular drugs including anticoagulants, antiarrhythmics, and lipid-lowering agents

Torsemide

Respiratory

1

Pharmacokinetic simulators for Respiratory therapeutics

Theophylline TDM

Cardiovascular / Lipid Disorders

1

Pharmacokinetic simulators for Cardiovascular / Lipid Disorders therapeutics

evinacumab

Oncology / Neuro-oncology

1

Cancer pharmacotherapy including chemotherapy, targeted therapy, immunotherapy, and ADCs

trastuzumab csf

Immunology / Respiratory

1

Immune-mediated diseases including rheumatoid arthritis, psoriasis, and atopic dermatitis

test

Oncology / HER2+ Breast Cancer

1

Cancer pharmacotherapy including chemotherapy, targeted therapy, immunotherapy, and ADCs

TMDD

Oncology (HER2+ Breast Cancer)

1

Cancer pharmacotherapy including chemotherapy, targeted therapy, immunotherapy, and ADCs

TMDD

Oncology / Prostate Cancer

1

Cancer pharmacotherapy including chemotherapy, targeted therapy, immunotherapy, and ADCs

Flutamide PBPK

Neuropathic Pain

1

Analgesics and pain management agents

Tramadol

Emergency Medicine / Opioid Overdose

1

Pharmacokinetic simulators for Emergency Medicine / Opioid Overdose therapeutics

Test

Opioid Overdose / Emergency Medicine

1

Pharmacokinetic simulators for Opioid Overdose / Emergency Medicine therapeutics

Test

Oncology — Ovarian Cancer

1

Cancer pharmacotherapy including chemotherapy, targeted therapy, immunotherapy, and ADCs

fda ruc

Hematology / Hemophilia A

1

Blood disorder treatments including hemophilia therapies

Kovaltry

Psychiatry / CNS

1

Psychotropic medications including antidepressants and antipsychotics

Sertraline

Genetic Medicine / RNA Therapeutics

1

Pharmacokinetic simulators for Genetic Medicine / RNA Therapeutics therapeutics

siRNA

Obstetrics

1

Pharmacokinetic simulators for Obstetrics therapeutics

Maternal-Fetal

CNS

1

Pharmacokinetic simulators for CNS therapeutics

Risperidone D2RO

Metastatic Colorectal Cancer

1

Pharmacokinetic simulators for Metastatic Colorectal Cancer therapeutics

Fruquintinib

Rheumatology

1

Pharmacokinetic simulators for Rheumatology therapeutics

PKPD

Gastroenterology

1

GI drugs including inflammatory bowel disease therapies

Entyvio (Vedolizumab)
← All SimulatorsCompare by Drug Class →