Pharmacokinetics Simulators by Therapeutic Area

Browse 228+ free interactive PK simulators organized by therapeutic area. Each area includes drug-specific models with dosing, covariate effects, and exposure metrics.

Oncology

54

Cancer pharmacotherapy including chemotherapy, targeted therapy, immunotherapy, and ADCs

ADC Effector FunctionDoxorubicinTrastuzumab (Herceptin) PBPK-TMDDPBPK-PD Topo1-Based ADC+50

Immunology

15

Immune-mediated diseases including rheumatoid arthritis, psoriasis, and atopic dermatitis

Enbrel (Etanercept)Orencia (Abatacept)Betamethasone MetaboliteBetamethasone NCA+11

Infectious Disease

14

Anti-infective agents including antibiotics, antivirals, and antifungals

Gentamicin TDMAntibiotic PD InteractionVoriconazole MIPDOxfendazole Population+10

Endocrinology

10

Metabolic and endocrine drugs including GLP-1 agonists, SGLT2 inhibitors, and insulin

Mounjaro (Tirzepatide)TirzepatideZepbound (Tirzepatide) DosingOzempic (Semaglutide)+6

Cardiology

10

Cardiovascular drugs including anticoagulants, antiarrhythmics, and lipid-lowering agents

Asundexian FXIa InhibitorDigoxinEliquis (Apixaban)Entresto (Sacubitril/Valsartan)+6

Neurology

6

Neurological drugs including anticonvulsants and disease-modifying therapies

Carbamazepine TDMPhenytoin TDML-dopaldopa 2+2

Transplant

5

Immunosuppressive agents for organ transplant rejection prophylaxis

Cyclosporine TDMTacrolimus TDMCyclosporineMycophenolate+1

Platform

5

General-purpose PK/PD modeling frameworks and tools

QSP PlatformPopPK FrameworkMinimal Antibody PBPKmAb PBPK (Shah-Betts)+1

Rare Disease

4

Orphan drugs for rare genetic and metabolic disorders

DonidalorsenmRNA-3927Givosiran ALAGivosiran

Oncology / NSCLC

3

Cancer pharmacotherapy including chemotherapy, targeted therapy, immunotherapy, and ADCs

RMCPatritumab Deruxtecan (HER3-DXd)poppk

Cardiovascular

3

Pharmacokinetic simulators for Cardiovascular therapeutics

Losartan and EXP3174Digoxin TDMWarfarin

Obstetrics / Maternal-Fetal Medicine

3

Pharmacokinetic simulators for Obstetrics / Maternal-Fetal Medicine therapeutics

Magnesium SulphateMagnesium SulphateNCA BET

Psychiatry

3

Psychotropic medications including antidepressants and antipsychotics

VortioxetinePKPD-NN_DMTInvega Sustenna (Paliperidone Palmitate)

Hematology

3

Blood disorder treatments including hemophilia therapies

Hemlibra (Emicizumab)PopulationConcizumab

Metabolic

3

Metabolic disease drugs including diabetes, obesity, and lipid disorders

SemaglutideInsulinWeight-HbA1c-Glucose

Pulmonology

3

Respiratory and pulmonary disease therapeutics

TheophyllineOfev (Nintedanib)Trikafta (Elexacaftor/Tezacaftor/Ivacaftor)

Oncology / HER2+ Breast Cancer

3

Cancer pharmacotherapy including chemotherapy, targeted therapy, immunotherapy, and ADCs

TrastuzumabTMDDTMDD

Pain

2

Analgesics and pain management agents

AcetaminophenMorphine

Respiratory / Inflammatory disease

2

Pharmacokinetic simulators for Respiratory / Inflammatory disease therapeutics

TozorakimabTozorakimab popkpd

Oncology / Ovarian Cancer

2

Cancer pharmacotherapy including chemotherapy, targeted therapy, immunotherapy, and ADCs

Mirvetuximab Soravtansine (ELAHERE)Rucaparib

Infectious Disease / Critical Care

2

Anti-infective agents including antibiotics, antivirals, and antifungals

Cefepime "Jonckheere"Linezolid

Ophthalmology

2

Ophthalmic drugs for retinal and macular diseases

Vabysmo (Faricimab)Eylea (Aflibercept)

Infectious Disease - Tuberculosis

2

Anti-infective agents including antibiotics, antivirals, and antifungals

Bedaquiline trialRifapentine

Atopic dermatitis

2

Pharmacokinetic simulators for Atopic dermatitis therapeutics

PKPK

Infectious disease

2

Anti-infective agents including antibiotics, antivirals, and antifungals

linezolidelinezolide

Pediatric neuro-oncology

1

Cancer pharmacotherapy including chemotherapy, targeted therapy, immunotherapy, and ADCs

PKPD

Nephrology

1

Pharmacokinetic simulators for Nephrology therapeutics

Population

Hypertension / Urology

1

Pharmacokinetic simulators for Hypertension / Urology therapeutics

Abc

Infectious Disease - Critical Care

1

Anti-infective agents including antibiotics, antivirals, and antifungals

Amikacine

Veterinary infectious disease

1

Anti-infective agents including antibiotics, antivirals, and antifungals

Thessaaloniki

Immunology / Dermatology

1

Immune-mediated diseases including rheumatoid arthritis, psoriasis, and atopic dermatitis

Risankizumab

Oncology / Breast Cancer

1

Cancer pharmacotherapy including chemotherapy, targeted therapy, immunotherapy, and ADCs

T-DXd (Enhertu) PBPK-PD ILD Risk

Obstetrics / Maternal Medicine

1

Pharmacokinetic simulators for Obstetrics / Maternal Medicine therapeutics

Magnesium Sulphate

Psychiatry / Neurology

1

Neurological drugs including anticonvulsants and disease-modifying therapies

Tapering- Venlafaxine

Neurology / Epilepsy

1

Neurological drugs including anticonvulsants and disease-modifying therapies

OXZ_PopPK

Oncology — Acute Lymphoblastic Leukemia

1

Cancer pharmacotherapy including chemotherapy, targeted therapy, immunotherapy, and ADCs

MTXPK

Gastrointestinal oncology

1

Cancer pharmacotherapy including chemotherapy, targeted therapy, immunotherapy, and ADCs

PopPK

Transthyretin Amyloidosis (ATTR)

1

Pharmacokinetic simulators for Transthyretin Amyloidosis (ATTR) therapeutics

Eplontersen

Hereditary Transthyretin Amyloidosis (hATTR)

1

Pharmacokinetic simulators for Hereditary Transthyretin Amyloidosis (hATTR) therapeutics

Inotersen

Infectious Disease / Transplant

1

Anti-infective agents including antibiotics, antivirals, and antifungals

Modèle Caldes

Transplantation / Infectious Disease

1

Anti-infective agents including antibiotics, antivirals, and antifungals

Modèle Chen

Transplant Medicine / Infectious Disease

1

Anti-infective agents including antibiotics, antivirals, and antifungals

Implémentation modèle Vezina

Transplant Infectious Disease / CMV

1

Anti-infective agents including antibiotics, antivirals, and antifungals

Pediatric Ganciclovir / Valganciclovir

Oncology / Hematologic malignancies

1

Cancer pharmacotherapy including chemotherapy, targeted therapy, immunotherapy, and ADCs

BGB-16673 BTK Degrader

Anesthesia

1

Pharmacokinetic simulators for Anesthesia therapeutics

Midazolam

Pediatric Infectious Disease / Neonatology

1

Anti-infective agents including antibiotics, antivirals, and antifungals

Piperacillin

HIV Prevention

1

Pharmacokinetic simulators for HIV Prevention therapeutics

VRC07-523-LS

Transplant / Immunosuppression

1

Immunosuppressive agents for organ transplant rejection prophylaxis

Tacro2

Transplant Immunosuppression

1

Immunosuppressive agents for organ transplant rejection prophylaxis

Tacrolimus (Advagraf)

Transplantation / Nephrology

1

Immunosuppressive agents for organ transplant rejection prophylaxis

Tacrolimus

Hematology / Transplantation

1

Immunosuppressive agents for organ transplant rejection prophylaxis

Tacrolimus pop

Oncology supportive care

1

Cancer pharmacotherapy including chemotherapy, targeted therapy, immunotherapy, and ADCs

glucarpidase

Tuberculosis

1

Pharmacokinetic simulators for Tuberculosis therapeutics

Moxifloxacin Pediatric

Type 2 Diabetes / Metabolic Disease

1

Metabolic disease drugs including diabetes, obesity, and lipid disorders

Efsubaglutide Alfa

Obesity / Weight Management

1

Pharmacokinetic simulators for Obesity / Weight Management therapeutics

semaglutide

Rare disease

1

Orphan drugs for rare genetic and metabolic disorders

Ayyar mPBPK

General

1

Pharmacokinetic simulators for General therapeutics

PK

Dermatology / Immunology

1

Immune-mediated diseases including rheumatoid arthritis, psoriasis, and atopic dermatitis

ORKA-002 HS

Immunology / Dermatology / Rheumatology

1

Immune-mediated diseases including rheumatoid arthritis, psoriasis, and atopic dermatitis

Bimzlex

Immunology/Dermatology

1

Immune-mediated diseases including rheumatoid arthritis, psoriasis, and atopic dermatitis

ORKA-002

Immunology / Antiparasitic / Oncology (adjuvant)

1

Cancer pharmacotherapy including chemotherapy, targeted therapy, immunotherapy, and ADCs

Levamisole

HIV / Infectious Disease

1

Anti-infective agents including antibiotics, antivirals, and antifungals

Dolutegravir

Platform QA

1

General-purpose PK/PD modeling frameworks and tools

Test Application

Hematology / Iron deficiency

1

Blood disorder treatments including hemophilia therapies

POPULATION

Cardiology / Nephrology

1

Cardiovascular drugs including anticoagulants, antiarrhythmics, and lipid-lowering agents

Torsemide

Oncology / Acute myeloid leukemia

1

Cancer pharmacotherapy including chemotherapy, targeted therapy, immunotherapy, and ADCs

Ziftomenib in Relapsed or Refractory Acute Myeloid Leukemia Patients

Respiratory

1

Pharmacokinetic simulators for Respiratory therapeutics

Theophylline TDM

Cardiovascular / Lipid Disorders

1

Pharmacokinetic simulators for Cardiovascular / Lipid Disorders therapeutics

evinacumab

Oncology / Neuro-oncology

1

Cancer pharmacotherapy including chemotherapy, targeted therapy, immunotherapy, and ADCs

trastuzumab csf

Immunology / Respiratory

1

Immune-mediated diseases including rheumatoid arthritis, psoriasis, and atopic dermatitis

Dupilumab (Dupixent)

Dermatology / Chronic pruritic disorders

1

Pharmacokinetic simulators for Dermatology / Chronic pruritic disorders therapeutics

Vixarelimab

Oncology / Prostate Cancer

1

Cancer pharmacotherapy including chemotherapy, targeted therapy, immunotherapy, and ADCs

Flutamide

Pain / Neurology

1

Neurological drugs including anticonvulsants and disease-modifying therapies

Tramadol

Emergency Medicine / Opioid Overdose

1

Pharmacokinetic simulators for Emergency Medicine / Opioid Overdose therapeutics

Intranasal Nalmefene vs Naloxone

Opioid Overdose / Emergency Medicine

1

Pharmacokinetic simulators for Opioid Overdose / Emergency Medicine therapeutics

Intranasal Nalmefene vs Naloxone Translational

Alzheimer's disease

1

Pharmacokinetic simulators for Alzheimer's disease therapeutics

VG

Environmental toxicology

1

Pharmacokinetic simulators for Environmental toxicology therapeutics

PFBS chloe

Hematology / Hemophilia A

1

Blood disorder treatments including hemophilia therapies

Kovaltry

Oncology supportive care / toxicology

1

Cancer pharmacotherapy including chemotherapy, targeted therapy, immunotherapy, and ADCs

Pipeline smoke test - Glucarpidase

Type 2 Diabetes

1

Pharmacokinetic simulators for Type 2 Diabetes therapeutics

Empagliflozin

Psychiatry / CNS

1

Psychotropic medications including antidepressants and antipsychotics

Sertraline

Genetic Medicine / RNA Therapeutics

1

Pharmacokinetic simulators for Genetic Medicine / RNA Therapeutics therapeutics

siRNA

Obstetrics

1

Pharmacokinetic simulators for Obstetrics therapeutics

Maternal-Fetal

CNS

1

Pharmacokinetic simulators for CNS therapeutics

Risperidone D2RO

Veterinary infectious diseases

1

Anti-infective agents including antibiotics, antivirals, and antifungals

Population

Inflammation and Autoimmune Disease

1

Pharmacokinetic simulators for Inflammation and Autoimmune Disease therapeutics

SDC-1801

Invasive fungal infections

1

Pharmacokinetic simulators for Invasive fungal infections therapeutics

PopPK for Voriconazole in pediatrics

Oncology / Metastatic Colorectal Cancer

1

Cancer pharmacotherapy including chemotherapy, targeted therapy, immunotherapy, and ADCs

Fruquintinib

Rheumatology

1

Pharmacokinetic simulators for Rheumatology therapeutics

PKPD

Gastroenterology

1

GI drugs including inflammatory bowel disease therapies

Entyvio (Vedolizumab)
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