About PKPDBuilder
Built by a pharmacometrician who got tired of rebuilding the same PK models from scratch.
Husain Attarwala, PhD
Founder, PKPDBuilder
Pharmacometrician · Drug Developer · 16+ years in Pharma
Husain is a pharmacometrician with 16+ years building PK/PD models for RNA therapeutics, monoclonal antibodies, and small molecules across the pharmaceutical industry. He built PKPDBuilder to give scientists free, instant access to the pharmacokinetic models buried in published literature — no coding, no server setup, no subscription.
His research spans GalNAc-siRNA pharmacokinetics (patisiran, vutrisiran), mRNA-encoded antibodies (Chikungunya, HIV bNAbs), and model-informed drug development for rare diseases. He holds a PhD in Pharmaceutical Sciences from Northeastern University.
Selected Publications
- ▸Impact of enhanced metabolic stability on pharmacokinetics and pharmacodynamics of GalNAc–siRNA conjugates— Nucleic Acids Research, 2017 · 301 citations
- ▸A phase 1 trial of lipid-encapsulated mRNA encoding a monoclonal antibody with neutralizing activity against Chikungunya virus— Nature Medicine, 2021 · 187 citations
- ▸Single-dose pharmacokinetics and pharmacodynamics of vutrisiran (ALN-TTRsc02) in healthy subjects— Clinical Pharmacology & Therapeutics, 2021 · 173 citations
- ▸Patisiran pharmacokinetics, pharmacodynamics, and exposure–response analyses in the phase 3 APOLLO trial— Journal of Clinical Pharmacology, 2020 · 134 citations
- ▸Translational PK/PD model for mRNA-3927, an investigational therapeutic for propionic acidemia— Nucleic Acid Therapeutics, 2023 · 38 citations
Sunny ☀️
AI Engineering Assistant
Sunny handles app generation, parameter extraction, and deployment. Built on Claude by Anthropic — extracts PK/PD parameters from uploaded manuscripts and builds R Shiny simulators automatically.