Pharmacokinetics Guides

Comprehensive PK parameter guides for 198+ drugs. Each guide includes key pharmacokinetic data, dosing information, and an interactive simulator.

All (198)Anesthesia (1)CNS (1)Cardiology (10)Cardiology / Nephrology (1)Cardiovascular (3)Cardiovascular / Lipid Disorders (1)Dermatology / Chronic pruritic disorders (1)Dermatology / Immunology (1)Emergency Medicine / Opioid Overdose (1)Endocrinology (8)Gastroenterology (1)Genetic Medicine / RNA Therapeutics (1)HIV / Infectious Disease (1)HIV Prevention (1)Hematology (2)Hematology / Hemophilia A (1)Hematology / Transplantation (1)Hereditary Transthyretin Amyloidosis (hATTR) (1)Hypertension / Urology (1)Immunology (16)Immunology / Antiparasitic / Oncology (adjuvant) (1)Immunology/Dermatology (1)Infectious Disease (14)Infectious Disease - Critical Care (1)Infectious Disease - Tuberculosis (2)Infectious Disease / Critical Care (2)Infectious Disease / Transplant (1)Metabolic (3)Neurology (4)Neurology / Epilepsy (1)Obesity / Weight Management (1)Obstetrics (1)Obstetrics / Maternal Medicine (1)Obstetrics / Maternal-Fetal Medicine (3)Oncology (50)Oncology / Acute myeloid leukemia (1)Oncology / Breast Cancer (1)Oncology / HER2+ Breast Cancer (3)Oncology / Metastatic Colorectal Cancer (1)Oncology / NSCLC (3)Oncology / Neuro-oncology (1)Oncology / Ovarian Cancer (2)Oncology / Prostate Cancer (1)Oncology supportive care (1)Oncology supportive care / toxicology (1)Oncology — Acute Lymphoblastic Leukemia (1)Ophthalmology (2)Opioid Overdose / Emergency Medicine (1)Pain (2)Pain / Neurology (1)Pediatric Infectious Disease / Neonatology (1)Platform (5)Platform QA (1)Psychiatry (2)Psychiatry / CNS (1)Psychiatry / Neurology (1)Pulmonology (3)Rare Disease (4)Rare disease (1)Respiratory (1)Respiratory / Inflammatory disease (1)Rheumatology (1)Transplant (5)Transplant / Immunosuppression (1)Transplant Immunosuppression (1)Transplant Medicine / Infectious Disease (1)Transplantation / Infectious Disease (1)Transplantation / Nephrology (1)Transthyretin Amyloidosis (ATTR) (1)Tuberculosis (1)Type 2 Diabetes (1)Type 2 Diabetes / Metabolic Disease (1)
OncologyPK/PD model with 2-compartment Michaelis-Menten PK and Friberg myelosuppression PD

5-FU A Tool for Predicting Pharmacokinetic–Pharmacodynamic/Toxicodynamic Responses Pharmacokinetics Guide

Colorectal cancer and other gastrointestinal malignancies treated with infusional 5-FU regimens

Fluoropyrimidine antimetabolite

Read guide →
OncologypopPK

5-Fluorouracil Pharmacokinetics Guide

Cancer chemotherapy

Antimetabolite

Read guide →
OncologyPK/PD

ADC Effector Function Model Pharmacokinetics Guide

Solid Tumors

ADC

Read guide →
OncologyPopulation PK

ADCs Pharmacokinetics Guide

HER2-positive breast cancer, NSCLC, gastric/GEJ cancer

Antibody-Drug Conjugate (ADC)

Read guide →
Hypertension / UrologyPopulation PK

Abc Pharmacokinetics Guide

Benign prostatic hyperplasia and hypertension

Alpha-1 Adrenoceptor Antagonist

Read guide →
PainpopPK

Acetaminophen Pharmacokinetics Guide

Pain/Fever

Analgesic

Read guide →
Infectious Disease - Critical CarePopPK

Amikacine Pharmacokinetics Guide

Severe infections in ICU patients including sepsis and nosocomial pneumonia

Aminoglycoside antibiotic

Read guide →
ImmunologyPopPK

Amlitelimab Pharmacokinetics Guide

Atopic Dermatitis

mAb

Read guide →
Infectious DiseasePharmacodynamic Interaction

Antibiotic PD Interaction Pharmacokinetics Guide

Bacterial infections

Antibiotics

Read guide →
CardiologyPK/PD

Asundexian FXIa Inhibitor Pharmacokinetics Guide

Anticoagulation

Small Molecule

Read guide →
Rare diseaseMechanistic translational PBPK-PD

Ayyar mPBPK Pharmacokinetics Guide

Acute hepatic porphyria

GalNAc-siRNA

Read guide →
OncologyPopPK

BTK Degrader Pharmacokinetics Guide

B-cell Malignancies

PROTAC

Read guide →
OncologyPK/PD

BTK Targeted Degrader Pharmacokinetics Guide

B-cell Malignancies

PROTAC

Read guide →
Infectious Disease - TuberculosisPopPK

Bedaquiline trial Pharmacokinetics Guide

Multi-drug resistant tuberculosis (MDR-TB)

Diarylquinoline antimycobacterial

Read guide →
ImmunologyPopPK

Betamethasone Metabolite Pharmacokinetics Guide

Inflammation/Preterm Labor

Small Molecule

Read guide →
ImmunologyNCA

Betamethasone NCA Pharmacokinetics Guide

Inflammation

Small Molecule

Read guide →
Infectious Disease1-CMT PopPK

Biktarvy (Bictegravir/Emtricitabine/TAF) Pharmacokinetics Guide

HIV-1 infection

Small Molecule

Read guide →
Immunology

Bimzlex Pharmacokinetics Guide

Monoclonal antibody

Read guide →
OncologySequential metabolite PopPK (capecitabine to 5'-DFCR to 5'-DFUR to 5-FU)

Capecitabine and 5-FU Pharmacokinetics Guide

Colorectal cancer, breast cancer, and gastric or gastroesophageal adenocarcinoma

Fluoropyrimidine / Oral Prodrug

Read guide →
NeurologypopPK

Carbamazepine TDM Pharmacokinetics Guide

Epilepsy

Anticonvulsant

Read guide →
Infectious Disease / Critical CarePopulation PK

Cefepime "Jonckheere" Pharmacokinetics Guide

Severe Gram-negative and nosocomial infections in critically ill ICU patients

Beta-Lactam Antibiotic (4th-gen Cephalosporin)

Read guide →
Infectious DiseasepopPK

Ciprofloxacin Pharmacokinetics Guide

Bacterial infections

Fluoroquinolone

Read guide →
OncologypopPK

Cisplatin Pharmacokinetics Guide

Cancer chemotherapy

Platinum

Read guide →
HematologyPK/PD

Concizumab Pharmacokinetics Guide

Hemophilia

mAb

Read guide →
Immunology1-CMT PopPK

Cosentyx (Secukinumab) Pharmacokinetics Guide

Plaque psoriasis

mAb

Read guide →
TransplantPopPK

Cyclosporine Pharmacokinetics Guide

Organ Transplant Rejection

Small Molecule

Read guide →
TransplantpopPK

Cyclosporine TDM Pharmacokinetics Guide

Transplant immunosuppression

Calcineurin inhibitor

Read guide →
NeurologyPopPK

DAC Pharmacokinetics Guide

Multiple Sclerosis

Monoclonal Antibody (Anti-CD25)

Read guide →
Oncology2-CMT PopPK

Darzalex (Daratumumab) Pharmacokinetics Guide

Multiple myeloma

mAb

Read guide →
OncologyPopulation PK

Dato Pharmacokinetics Guide

TROP2-positive metastatic breast cancer and other TROP2-expressing solid tumors

Antibody-Drug Conjugate (ADC)

Read guide →
OncologyPopulation PK (2-CMT ADC parallel linear+MM + 1-CMT Payload)

Datopotamab Deruxtecan (Datroway) Pharmacokinetics Guide

Locally advanced or metastatic non-squamous NSCLC (TROPION-Lung08), HR+/HER2-low/negative metastatic breast cancer (TROPION-Breast01), and triple-negative breast cancer; TROP2-directed ADC with DXd payload

Antibody-Drug Conjugate (ADC)

Read guide →
CardiologyPopPK

Digoxin Pharmacokinetics Guide

Heart Failure / Atrial Fibrillation

Small Molecule

Read guide →
CardiovascularpopPK

Digoxin TDM Pharmacokinetics Guide

Heart failure/AF

Cardiac glycoside

Read guide →
Oncology3-compartment PopPK with covariate effects

Docetaxel Pharmacokinetics Guide

Breast cancer, non-small cell lung cancer, prostate cancer, gastric cancer, and head and neck cancer

Taxane / Microtubule stabilizer

Read guide →
HIV / Infectious DiseasePopulation PK

Dolutegravir Pharmacokinetics Guide

HIV-1 infection

Integrase Strand Transfer Inhibitor (INSTI)

Read guide →
Rare DiseasePK/PD

Donidalorsen Pharmacokinetics Guide

Hereditary Angioedema

ASO

Read guide →
OncologypopPK

Doxorubicin Pharmacokinetics Guide

Cancer chemotherapy

Anthracycline

Read guide →
ImmunologyPopPK

Dupilumab Pharmacokinetics Guide

Atopic Dermatitis

mAb

Read guide →
ImmunologyPopPK

Dupilumab Population Pharmacokinetics Guide

Atopic Dermatitis

mAb

Read guide →
Immunology1-CMT PopPK

Dupixent (Dupilumab) Pharmacokinetics Guide

Atopic dermatitis

mAb

Read guide →
Type 2 Diabetes / Metabolic DiseasePopulation PK

Efsubaglutide Alfa Pharmacokinetics Guide

Type 2 diabetes mellitus

GLP-1 Receptor Agonist

Read guide →
Cardiology1-CMT PopPK

Eliquis (Apixaban) Pharmacokinetics Guide

Stroke prevention in atrial fibrillation

Small Molecule

Read guide →
Type 2 DiabetesPopPK + Exposure-Response

Empagliflozin Pharmacokinetics Guide

Type 2 Diabetes Mellitus

SGLT2 inhibitor

Read guide →
Immunology1-CMT PopPK

Enbrel (Etanercept) Pharmacokinetics Guide

Rheumatoid arthritis

Fusion Protein

Read guide →
OncologyPopulation PK (Sequential 2-CMT ADC + 1-CMT Payload)

Enhertu Pharmacokinetics Guide

HER2-positive breast cancer, gastric/gastroesophageal adenocarcinoma, NSCLC

Antibody-Drug Conjugate (ADC)

Read guide →
Cardiology2-CMT PopPK

Entresto (Sacubitril/Valsartan) Pharmacokinetics Guide

Heart failure with reduced ejection fraction

Small Molecule

Read guide →
Gastroenterology2-CMT PopPK

Entyvio (Vedolizumab) Pharmacokinetics Guide

Ulcerative colitis

mAb

Read guide →
Transthyretin Amyloidosis (ATTR)2-CMT PK + Indirect Response PD

Eplontersen Pharmacokinetics Guide

Hereditary transthyretin-mediated amyloidosis (hATTR)

Antisense Oligonucleotide (ASO)

Read guide →
Ophthalmology2-CMT PopPK

Eylea (Aflibercept) Pharmacokinetics Guide

Wet age-related macular degeneration

Fusion Protein

Read guide →
Endocrinology1-CMT PopPK

Farxiga (Dapagliflozin) Pharmacokinetics Guide

Type 2 diabetes mellitus

Small Molecule

Read guide →
Oncology / Prostate CancerPBPK-Derived Parent-Metabolite (1-CMT per species)

Flutamide Pharmacokinetics Guide

Stage D2 metastatic prostate cancer (combined with LHRH agonist)

Non-steroidal Antiandrogen

Read guide →
Oncology / Metastatic Colorectal CancerPopulation PK

Fruquintinib Pharmacokinetics Guide

Previously treated metastatic colorectal cancer

VEGFR Tyrosine Kinase Inhibitor

Read guide →
Infectious DiseasePK/PD

Ganciclovir Pharmacokinetics Guide

CMV Infection

Small Molecule

Read guide →
Infectious DiseasepopPK

Gentamicin TDM Pharmacokinetics Guide

Bacterial infections

Aminoglycoside

Read guide →
Rare DiseasePK/PD

Givosiran ALA Pharmacokinetics Guide

Acute Hepatic Porphyria

siRNA

Read guide →
Rare DiseasePK/PD

Givosiran Pharmacokinetics Guide

Acute Hepatic Porphyria

siRNA

Read guide →
Hematology2-CMT PopPK

Hemlibra (Emicizumab) Pharmacokinetics Guide

Hemophilia A

Bispecific mAb

Read guide →
Immunology2-CMT PopPK

Humira (Adalimumab) Pharmacokinetics Guide

Rheumatoid arthritis

mAb

Read guide →
Oncology1-CMT PopPK

Ibrance (Palbociclib) Pharmacokinetics Guide

HR+/HER2- metastatic breast cancer

Small Molecule

Read guide →
OncologyPopPK

Imatinib Pharmacokinetics Guide

CML / GIST

Small Molecule

Read guide →
Oncology1-CMT PopPK

Imbruvica (Ibrutinib) Pharmacokinetics Guide

Chronic lymphocytic leukemia

Small Molecule

Read guide →
Oncology2-CMT PopPK

Imfinzi (Durvalumab) Pharmacokinetics Guide

Non-small cell lung cancer

mAb

Read guide →
Transplant Medicine / Infectious DiseasePopulation PK

Implémentation modèle Vezina Pharmacokinetics Guide

CMV prophylaxis in solid organ transplant recipients

Antiviral — Nucleoside Analogue

Read guide →
OncologyPopPK

Infigratinib Pharmacokinetics Guide

Cholangiocarcinoma

Small Molecule

Read guide →
Hereditary Transthyretin Amyloidosis (hATTR)Population PK/PD

Inotersen Pharmacokinetics Guide

Hereditary transthyretin-mediated amyloidosis with polyneuropathy

Antisense Oligonucleotide (ASO)

Read guide →
MetabolicpopPK

Insulin Pharmacokinetics Guide

DKA/Diabetes

Hormone

Read guide →
Emergency Medicine / Opioid OverdosePopulation PK

Intranasal Nalmefene vs Naloxone Pharmacokinetics Guide

Emergency reversal of opioid overdose including fentanyl exposure

Opioid Antagonists

Read guide →
Opioid Overdose / Emergency MedicineTranslational PK-PD

Intranasal Nalmefene vs Naloxone Translational Model Pharmacokinetics Guide

Emergency reversal of opioid overdose including potent synthetic opioids

Opioid Receptor Antagonists

Read guide →
Psychiatry2-CMT PopPK

Invega Sustenna (Paliperidone Palmitate) Pharmacokinetics Guide

Schizophrenia

Small Molecule

Read guide →
Endocrinology1-CMT PopPK

Jardiance (Empagliflozin) Pharmacokinetics Guide

Type 2 diabetes mellitus

Small Molecule

Read guide →
Oncology2-CMT PopPK

Keytruda (Pembrolizumab) Pharmacokinetics Guide

Melanoma and non-small cell lung cancer

mAb

Read guide →
OncologypopPK

Keytruda Pharmacokinetics Guide

Cancer immunotherapy

PD-1 inhibitor

Read guide →
Hematology / Hemophilia APopulation PK

Kovaltry Pharmacokinetics Guide

Hemophilia A prophylaxis and bleed treatment

Recombinant Factor VIII (Antihemophilic Factor)

Read guide →
Immunology / Antiparasitic / Oncology (adjuvant)Population PK

Levamisole Pharmacokinetics Guide

Anthelmintic use and immunomodulatory research applications

Imidazothiazole (Immunomodulant/Anthelmintic)

Read guide →
Infectious Disease / Critical Care1-compartment PopPK with IV infusion and PTA outputs

Linezolid Pharmacokinetics Guide

Severe Gram-positive infections in critically ill patients, including COVID-19 ARDS on VV-ECMO

Oxazolidinone antibiotic

Read guide →
CardiovascularPopulation PK

Losartan and EXP3174 Pharmacokinetics Guide

Hypertension

Angiotensin II Receptor Blocker (ARB)

Read guide →
Oncology1-CMT PopPK

Lynparza (Olaparib) Pharmacokinetics Guide

BRCA-mutated ovarian cancer

Small Molecule

Read guide →
Oncology — Acute Lymphoblastic Leukemia3-CMT PopPK

MTXPK Pharmacokinetics Guide

Acute lymphoblastic leukemia (ALL), osteosarcoma

Antifolate antineoplastic

Read guide →
Obstetrics / Maternal-Fetal Medicine1-compartment PopPK with IV and IM dosing

Magnesium Sulphate Pharmacokinetics Guide

Pre-eclampsia and eclampsia for maternal seizure prophylaxis and treatment

Anticonvulsant / Electrolyte

Read guide →
Obstetrics / Maternal-Fetal Medicine1-compartment PopPK with IV and IM dosing

Magnesium Sulphate Pharmacokinetics Guide

Pre-eclampsia and eclampsia for maternal seizure prophylaxis and treatment

Anticonvulsant / Electrolyte

Read guide →
Obstetrics / Maternal MedicinePopPK — 1-Compartment, IV/IM

Magnesium Sulphate Pharmacokinetics Guide

Pre-eclampsia and Eclampsia (seizure prophylaxis)

Anticonvulsant / Electrolyte

Read guide →
ObstetricsPopPK

Maternal-Fetal Pharmacokinetics Guide

Maternal-Fetal Medicine

Small Molecule

Read guide →
OncologypopPK

Methotrexate High-Dose Pharmacokinetics Guide

Cancer/RA

Antimetabolite

Read guide →
AnesthesiapopPK

Midazolam Pharmacokinetics Guide

Sedation

Benzodiazepine

Read guide →
PlatformPBPK

Minimal Antibody PBPK Pharmacokinetics Guide

Monoclonal Antibodies

mAb

Read guide →
Oncology / Ovarian CancerPopulation PK (2-CMT ADC + 1-CMT DM4 Payload)

Mirvetuximab Soravtansine (ELAHERE) Pharmacokinetics Guide

FRα-positive, platinum-resistant epithelial ovarian, fallopian tube, or primary peritoneal cancer; maytansinoid DM4 payload

Antibody-Drug Conjugate (ADC)

Read guide →
Infectious Disease / TransplantPopulation PK

Modèle Caldes Pharmacokinetics Guide

CMV treatment or prophylaxis in solid organ transplant recipients

Antiviral

Read guide →
Transplantation / Infectious DiseasePopulation PK

Modèle Chen Pharmacokinetics Guide

CMV prophylaxis in adult renal transplant recipients

Antiviral

Read guide →
PainpopPK

Morphine Pharmacokinetics Guide

Pain management

Opioid

Read guide →
Endocrinology1-CMT PopPK

Mounjaro (Tirzepatide) Pharmacokinetics Guide

Type 2 diabetes mellitus

Dual GIP/GLP-1 RA

Read guide →
TuberculosisPopulation PK

Moxifloxacin Pediatric Pharmacokinetics Guide

Pediatric rifampicin-resistant tuberculosis

Fluoroquinolone Antibiotic

Read guide →
TransplantPopPK

Mycophenolate Pharmacokinetics Guide

Organ Transplant Rejection

Small Molecule

Read guide →
Obstetrics / Maternal-Fetal MedicineNCA

NCA BET Pharmacokinetics Guide

Antenatal corticosteroid therapy for fetal lung maturation; placental transfer characterization

Corticosteroid

Read guide →
Dermatology / Immunology1-compartment SC PopPK

ORKA-002 HS Pharmacokinetics Guide

Hidradenitis suppurativa

Humanized IgG1 monoclonal antibody against IL-17A / IL-17F

Read guide →
Immunology/Dermatology1-compartment SC PopPK

ORKA-002 Pharmacokinetics Guide

Moderate to severe plaque psoriasis, psoriatic arthritis, non-radiographic axial spondyloarthritis, ankylosing spondylitis, and hidradenitis suppurativa

IL-17A/IL-17F monoclonal antibody

Read guide →
Neurology / Epilepsy1-CMT Joint Parent-Metabolite PopPK (PKWT-scaled allometric)

OXZ_PopPK Pharmacokinetics Guide

Partial-onset seizures in adults and children ≥ 2 years

Antiepileptic Drug (AED)

Read guide →
Neurology2-CMT PopPK

Ocrevus (Ocrelizumab) Pharmacokinetics Guide

Multiple sclerosis

mAb

Read guide →
Pulmonology1-CMT PopPK

Ofev (Nintedanib) Pharmacokinetics Guide

Idiopathic pulmonary fibrosis

Small Molecule

Read guide →
OncologyPK/PD

Oncology Dose Selection Tool Pharmacokinetics Guide

Solid Tumors

Small Molecule

Read guide →
Oncology2-CMT PopPK

Opdivo (Nivolumab) Pharmacokinetics Guide

Melanoma and non-small cell lung cancer

mAb

Read guide →
Immunology2-CMT PopPK

Orencia (Abatacept) Pharmacokinetics Guide

Rheumatoid arthritis

Fusion Protein

Read guide →
Infectious DiseasePopPK

Oxacillin Neonatal Pharmacokinetics Guide

MSSA Infections (Neonates)

Small Molecule

Read guide →
Infectious DiseasePopulation PK (1-CMT drug-metabolite, first-pass)

Oxfendazole Population Pharmacokinetics Guide

Onchocerciasis (river blindness)

Benzimidazole Anthelminthic

Read guide →
Endocrinology1-CMT PopPK

Ozempic (Semaglutide) Pharmacokinetics Guide

Type 2 diabetes mellitus

GLP-1 RA

Read guide →
OncologyPBPK-PD

PBPK-PD Topo1-Based ADC Pharmacokinetics Guide

Solid tumors (HER2-positive and Trop-2-positive cancers)

Antibody-Drug Conjugate

Read guide →
OncologyPBPK-PD Model

PBPK-PD Topo1-Based ADC Pharmacokinetics Guide

Solid tumors (breast, lung, gastric, colorectal cancer)

Antibody-Drug Conjugate (ADC)

Read guide →
OncologyPBPK-PD Model

PBPK-PD Topo1-Based ADC Pharmacokinetics Guide

Solid tumors (breast, lung, gastric, colorectal cancer)

Antibody-Drug Conjugate (ADC)

Read guide →
OncologyPBPK-PD

PBPK-PD of ADCs Pharmacokinetics Guide

Exposure and ILD risk assessment for trastuzumab deruxtecan and related ADC therapy

Antibody-Drug Conjugate (ADC)

Read guide →
RheumatologySemi-mechanistic PK/PD

PKPD model for lesinurad (Zurampic) Pharmacokinetics Guide

Hyperuricemia associated with gout

Xanthine Oxidase Inhibitors / Uricosurics

Read guide →
OncologypopPK

Paclitaxel Pharmacokinetics Guide

Cancer chemotherapy

Taxane

Read guide →
Oncology / NSCLCPopulation PK (2-CMT ADC + 1-CMT DXd Payload)

Patritumab Deruxtecan (HER3-DXd) Pharmacokinetics Guide

EGFR-mutant NSCLC after EGFR TKI and platinum therapy; HER3-directed ADC with DXd payload

Antibody-Drug Conjugate (ADC)

Read guide →
Infectious Disease1-CMT PopPK

Paxlovid (Nirmatrelvir/Ritonavir) Pharmacokinetics Guide

COVID-19 treatment

Small Molecule

Read guide →
Oncology2-CMT PopPK

Perjeta (Pertuzumab) Pharmacokinetics Guide

HER2-positive breast cancer

mAb

Read guide →
Oncology2-compartment PopPK

Pertuzumab Pharmacokinetics Guide

HER2-positive solid tumors

Monoclonal antibody

Read guide →
NeurologypopPK

Phenytoin TDM Pharmacokinetics Guide

Epilepsy

Anticonvulsant

Read guide →
Oncology supportive care / toxicologyTwo-compartment PK/PD with modified Michaelis-Menten enzymatic rescue

Pipeline smoke test - Glucarpidase Pharmacokinetics Guide

Rescue treatment for delayed methotrexate elimination and severe methotrexate toxicity after high-dose methotrexate therapy

Recombinant carboxypeptidase enzyme

Read guide →
Pediatric Infectious Disease / NeonatologyPopulation PK

Piperacillin Pharmacokinetics Guide

Neonatal sepsis and serious neonatal bacterial infection

Beta-lactam Antibiotic

Read guide →
Oncology1-CMT PopPK

Pomalyst (Pomalidomide) Pharmacokinetics Guide

Multiple myeloma

Small Molecule

Read guide →
PlatformPopPK

PopPK Framework Model Pharmacokinetics Guide

Drug Development

Small Molecule

Read guide →
CardiologyPopPK

Pravastatin EHC Model Pharmacokinetics Guide

Hypercholesterolemia

Statin

Read guide →
CardiologyPopPK

Pravastatin SLCO1B1 PGx Model Pharmacokinetics Guide

Hypercholesterolemia

Statin

Read guide →
Endocrinology2-CMT PopPK

Prolia (Denosumab) Pharmacokinetics Guide

Postmenopausal osteoporosis

mAb

Read guide →
PlatformQSP

QSP Platform Model Pharmacokinetics Guide

Drug Development

Platform

Read guide →
Oncology / NSCLCPopulation PK/PD

RMC Pharmacokinetics Guide

ALK-positive or ROS1-positive non-small cell lung cancer

ALK/ROS1 Tyrosine Kinase Inhibitor

Read guide →
Oncology1-CMT PopPK

Revlimid (Lenalidomide) Pharmacokinetics Guide

Multiple myeloma

Small Molecule

Read guide →
Infectious DiseasepopPK

Rifampicin Pharmacokinetics Guide

Tuberculosis

Rifamycin

Read guide →
Infectious Disease - TuberculosisPopPK

Rifapentine Pharmacokinetics Guide

Tuberculosis treatment and latent TB infection prophylaxis

Rifamycin antibiotic

Read guide →
Immunology1-CMT PopPK

Rinvoq (Upadacitinib) Pharmacokinetics Guide

Rheumatoid arthritis

Small Molecule

Read guide →
CNSPK/PD

Risperidone D2RO Pharmacokinetics Guide

Schizophrenia

Small Molecule

Read guide →
OncologySemi-mechanistic PK/PD

Ruc Pharmacokinetics Guide

BRCA-mutant and HRD+ breast cancer

PARP inhibitor

Read guide →
Oncology / Ovarian CancerPopulation PK

Rucaparib Pharmacokinetics Guide

BRCA-mutated advanced ovarian, fallopian tube, or primary peritoneal cancer

PARP Inhibitor

Read guide →
Endocrinology1-CMT PopPK

Rybelsus (Oral Semaglutide) Pharmacokinetics Guide

Type 2 diabetes mellitus

GLP-1 RA

Read guide →
OncologyPopulation PK (Triple-analyte: ADC + SN-38 payload + total antibody)

Sacituzumab Govitecan (Trodelvy) Pharmacokinetics Guide

Unresectable locally advanced or metastatic triple-negative breast cancer (mTNBC), HR+/HER2-negative metastatic breast cancer after endocrine and CDK4/6 inhibitor therapy, and locally advanced or metastatic urothelial cancer; TROP2-directed ADC with SN-38 payload

Antibody-Drug Conjugate (ADC)

Read guide →
MetabolicPK/PD

Semaglutide Pharmacokinetics Guide

Type 2 Diabetes / Obesity

GLP-1 RA

Read guide →
OncologyTwo-Compartment with Time-Dependent Clearance

Serplulimab (HLX10) Population Pharmacokinetics Guide

Extensive-Stage Small Cell Lung Cancer (ES-SCLC)

Monoclonal Antibody (anti-PD-1)

Read guide →
Psychiatry / CNSPopulation PK

Sertraline Pharmacokinetics Guide

Major depressive disorder and anxiety disorders

SSRI Antidepressant

Read guide →
CardiologyPopPK

Simvastatin Pharmacokinetics Guide

Hypercholesterolemia

Statin

Read guide →
Immunology2-CMT PopPK

Skyrizi (Risankizumab) Pharmacokinetics Guide

Plaque psoriasis

mAb

Read guide →
Immunology2-CMT PopPK

Stelara (Ustekinumab) Pharmacokinetics Guide

Plaque psoriasis

mAb

Read guide →
Oncology / Breast CancerPBPK-PD

T-DXd (Enhertu) PBPK-PD ILD Risk Pharmacokinetics Guide

HER2-positive metastatic breast cancer, gastric/GEJ adenocarcinoma, NSCLC, and other HER2-expressing solid tumors; ILD risk stratification and dose optimization

Antibody-Drug Conjugate (ADC)

Read guide →
OncologyPK/PD

T-cell Engager Pharmacokinetics Guide

Hematologic Malignancies

mAb

Read guide →
OncologyMinimal PBPK-TMDD with Target Shedding

TMDD Model Pharmacokinetics Guide

HER2-positive Breast Cancer

Monoclonal Antibody (Anti-HER2)

Read guide →
Oncology / HER2+ Breast CancerPBPK-TMDD

TMDD Model 3 Pharmacokinetics Guide

HER2-positive breast cancer

Monoclonal Antibody (anti-HER2)

Read guide →
Oncology / HER2+ Breast CancerPBPK-TMDD

TMDD Model 4 Pharmacokinetics Guide

HER2-positive breast cancer

Monoclonal Antibody (HER2-targeted)

Read guide →
Transplant / ImmunosuppressionPopPK (2-compartment)

Tacro2 Pharmacokinetics Guide

Allogeneic hematopoietic cell transplantation (allo-HCT)

Calcineurin Inhibitor

Read guide →
Transplant ImmunosuppressionPopulation PK

Tacrolimus (Advagraf) Pharmacokinetics Guide

Maintenance immunosuppression after kidney transplantation

Calcineurin Inhibitor

Read guide →
TransplantPopPK

Tacrolimus Pharmacokinetics Guide

Organ Transplant

Small Molecule

Read guide →
TransplantpopPK

Tacrolimus TDM Pharmacokinetics Guide

Transplant immunosuppression

Calcineurin inhibitor

Read guide →
Transplantation / NephrologyPopPK

Tacrolimus model Pharmacokinetics Guide

Kidney transplant immunosuppression

Calcineurin inhibitor (Immunosuppressant)

Read guide →
Hematology / TransplantationPopPK (2-compartment)

Tacrolimus pop Pharmacokinetics Guide

Pediatric/young adult hematopoietic cell transplantation

Calcineurin inhibitor (immunosuppressant)

Read guide →
Oncology1-CMT PopPK

Tagrisso (Osimertinib) Pharmacokinetics Guide

EGFR-mutated non-small cell lung cancer

Small Molecule

Read guide →
Psychiatry / Neurology1-compartment oral PK + Michaelis-Menten receptor occupancy (SERT / α₂-adrenergic)

Tapering- Venlafaxine Pharmacokinetics Guide

Major depressive disorder, generalized anxiety disorder — antidepressant tapering and withdrawal risk assessment

Antidepressants (SSRI, SNRI, NaSSA)

Read guide →
Oncology2-CMT PopPK

Tecentriq (Atezolizumab) Pharmacokinetics Guide

Non-small cell lung cancer

mAb

Read guide →
Platform QADemo / validation app

Test Application Pharmacokinetics Guide

Internal deployment testing

Internal test / placeholder

Read guide →
Pulmonology1-CMT PopPK

Theophylline Pharmacokinetics Guide

Asthma, COPD, neonatal apnea

Methylxanthine bronchodilator

Read guide →
RespiratorypopPK

Theophylline TDM Pharmacokinetics Guide

Asthma/COPD

Methylxanthine

Read guide →
Cardiology / NephrologyPopPK

Torsemide Pharmacokinetics Guide

Heart Failure, Edema

Loop Diuretic

Read guide →
Respiratory / Inflammatory diseaseTwo-compartment population PK / target engagement model

Tozorakimab Pharmacokinetics Guide

Chronic obstructive pulmonary disease (COPD)

Anti-IL-33 monoclonal antibody

Read guide →
Pain / NeurologyPopulation PK/PD

Tramadol Pharmacokinetics Guide

Neuropathic pain

Opioid Analgesic

Read guide →
OncologyMinimal PBPK-TMDD

Trastuzumab (Herceptin) PBPK-TMDD Pharmacokinetics Guide

HER2-positive breast cancer

Anti-HER2 Monoclonal Antibody

Read guide →
OncologyPopPK

Trastuzumab Pharmacokinetics Guide

HER2+ Breast Cancer

mAb

Read guide →
OncologyPopPK

Trastuzumab Pharmacokinetics Guide

HER2+ Breast Cancer

mAb

Read guide →
Oncology / HER2+ Breast CancerPopulation PK

Trastuzumab Pharmacokinetics Guide

HER2-positive metastatic breast cancer

Monoclonal Antibody

Read guide →
Immunology2-CMT PopPK

Tremfya (Guselkumab) Pharmacokinetics Guide

Plaque psoriasis

mAb

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Pulmonology1-CMT PopPK

Trikafta (Elexacaftor/Tezacaftor/Ivacaftor) Pharmacokinetics Guide

Cystic fibrosis

Small Molecule

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Endocrinology1-CMT PopPK

Trulicity (Dulaglutide) Pharmacokinetics Guide

Type 2 diabetes mellitus

GLP-1 RA

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OncologyPK/PD

Tumor Exposure Analysis Model Pharmacokinetics Guide

Solid Tumors

mAb

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HIV Prevention2-CMT PopPK

VRC07-523-LS Pharmacokinetics Guide

HIV prevention in infants and adults

Broadly Neutralizing Antibody (bNAb)

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Ophthalmology2-CMT PopPK

Vabysmo (Faricimab) Pharmacokinetics Guide

Wet age-related macular degeneration

Bispecific mAb

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Infectious DiseasePopPK

Vancomycin Hemodialysis Pharmacokinetics Guide

Serious gram-positive infections requiring IV vancomycin

Glycopeptide antibiotic

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Infectious DiseasepopPK

Vancomycin TDM Pharmacokinetics Guide

Bacterial infections

Glycopeptide

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Oncology1-CMT PopPK

Verzenio (Abemaciclib) Pharmacokinetics Guide

HR+/HER2- metastatic breast cancer

Small Molecule

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Dermatology / Chronic pruritic disorders2-compartment TMDD PopPK

Vixarelimab Pharmacokinetics Guide

Prurigo nodularis and chronic pruritic conditions

Monoclonal antibody

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Infectious DiseaseOne-compartment PopPK

Voriconazole Pharmacokinetics Guide

Invasive aspergillosis, candidemia

Triazole Antifungal

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Infectious DiseasePopPK

Voriconazole IV Pharmacokinetics Guide

Invasive Fungal Infections

Small Molecule

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Infectious DiseaseMIPD / nonlinear PopPK

Voriconazole MIPD Pharmacokinetics Guide

Invasive fungal infections

Antifungal

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PsychiatryPopPK + Emax PK/PD

Vortioxetine Pharmacokinetics Guide

Major Depressive Disorder (MDD)

Antidepressant (Multimodal)

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Cardiology1-CMT PopPK

Vyndaqel (Tafamidis) Pharmacokinetics Guide

Transthyretin amyloid cardiomyopathy

Small Molecule

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CardiovascularpopPK

Warfarin Pharmacokinetics Guide

Anticoagulation

Vitamin K antagonist

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CardiologyPK/PD

Warfarin Pharmacokinetics Guide

Anticoagulation

Small Molecule

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Endocrinology1-CMT PopPK

Wegovy (Semaglutide) Pharmacokinetics Guide

Chronic weight management

GLP-1 RA

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MetabolicPK/PD

Weight-HbA1c-Glucose Model Pharmacokinetics Guide

Obesity/T2DM

Small Molecule

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Cardiology1-CMT PopPK

Xarelto (Rivaroxaban) Pharmacokinetics Guide

Stroke prevention in atrial fibrillation

Small Molecule

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Immunology1-CMT PopPK

Xolair (Omalizumab) Pharmacokinetics Guide

Moderate-to-severe allergic asthma

mAb

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Oncology1-CMT PopPK

Xtandi (Enzalutamide) Pharmacokinetics Guide

Metastatic castration-resistant prostate cancer

Small Molecule

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Oncology / Acute myeloid leukemiaPopulation PK with linked metabolites

Ziftomenib in Relapsed or Refractory Acute Myeloid Leukemia Patients Pharmacokinetics Guide

Relapsed/refractory NPM1-mutated acute myeloid leukemia

Menin inhibitor

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Cardiovascular / Lipid Disorders2-CMT mixed elimination

evinacumab Pharmacokinetics Guide

HoFH

Monoclonal Antibody (ANGPTL3 Inhibitor)

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Oncology supportive careTwo-compartment PK/PD with modified Michaelis-Menten rescue

glucarpidase Pharmacokinetics Guide

Rescue treatment for delayed methotrexate elimination and toxicity after high-dose methotrexate therapy

Enzyme rescue therapy

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OncologyPopulation PK

lenvatinib_Gupta_26879594 Pharmacokinetics Guide

Advanced renal cell carcinoma, hepatocellular carcinoma, and differentiated thyroid cancer

Multikinase Inhibitor (TKI)

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PlatformPBPK

mAb PBPK (Shah-Betts) Pharmacokinetics Guide

Monoclonal Antibodies

mAb

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PlatformPK/PD

mAb TMDD Platform Model Pharmacokinetics Guide

Monoclonal Antibodies

mAb

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Rare DiseasePK/PD

mRNA-3927 Pharmacokinetics Guide

Propionic Acidemia

mRNA-LNP

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Oncology / NSCLCPopulation PK/Exposure-Response

poppk model of osimertinib Pharmacokinetics Guide

EGFR-mutated non-small cell lung cancer

EGFR Tyrosine Kinase Inhibitor

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OncologyPopPK (2-compartment)

rucaparib ok model Pharmacokinetics Guide

Ovarian cancer, metastatic castration-resistant prostate cancer (mCRPC)

PARP Inhibitor

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OncologyPopulation PK/PD

rucaparib Pharmacokinetics Guide

PARP-targeted therapy in advanced solid tumors including ovarian cancer

PARP Inhibitor

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Obesity / Weight ManagementPopulation PK/PD (1-CMT + Emax/Indirect Response)

semaglutide Pharmacokinetics Guide

Obesity (BMI ≥30) and overweight (BMI ≥27) with weight-related comorbidity; Type 2 Diabetes

GLP-1 Receptor Agonist

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Genetic Medicine / RNA TherapeuticsPKPD

siRNA Pharmacokinetics Guide

Various (gene silencing platform)

Small Interfering RNA (siRNA)

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Oncology / Neuro-oncologyPopulation PK

trastuzumab csf Pharmacokinetics Guide

HER2-positive breast cancer with leptomeningeal metastases

Monoclonal Antibody (Anti-HER2)

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