Pharmacokinetics Guides

Comprehensive PK parameter guides for 181+ drugs. Each guide includes key pharmacokinetic data, dosing information, and an interactive simulator.

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OncologypopPK

5-Fluorouracil Pharmacokinetics Guide

Cancer chemotherapy

Antimetabolite

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OncologyPK/PD

ADC Effector Function Model Pharmacokinetics Guide

Solid Tumors

ADC

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OncologyPopulation PK

ADCs Pharmacokinetics Guide

HER2-positive breast cancer, NSCLC, gastric/GEJ cancer

Antibody-Drug Conjugate (ADC)

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OncologyPopPK

BTK Degrader Pharmacokinetics Guide

B-cell Malignancies

PROTAC

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OncologyPK/PD

BTK Targeted Degrader Pharmacokinetics Guide

B-cell Malignancies

PROTAC

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OncologypopPK

Cisplatin Pharmacokinetics Guide

Cancer chemotherapy

Platinum

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Oncology2-CMT PopPK

Darzalex (Daratumumab) Pharmacokinetics Guide

Multiple myeloma

mAb

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OncologyPopulation PK

Dato Pharmacokinetics Guide

TROP2-positive metastatic breast cancer

Antibody-Drug Conjugate (ADC)

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OncologyPopulation PK (2-CMT ADC parallel linear+MM + 1-CMT Payload)

Datroway Pharmacokinetics Guide

Locally advanced or metastatic non-squamous NSCLC (TROPION-Lung08), HR+/HER2-low/negative metastatic breast cancer (TROPION-Breast01), and triple-negative breast cancer; TROP2-directed ADC with DXd payload

Antibody-Drug Conjugate (ADC)

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OncologypopPK

Doxorubicin Pharmacokinetics Guide

Cancer chemotherapy

Anthracycline

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OncologyPopulation PK (Sequential 2-CMT ADC + 1-CMT Payload)

Enhertu Pharmacokinetics Guide

HER2-positive breast cancer, gastric/gastroesophageal adenocarcinoma, NSCLC

Antibody-Drug Conjugate (ADC)

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Oncology1-CMT PopPK

Ibrance (Palbociclib) Pharmacokinetics Guide

HR+/HER2- metastatic breast cancer

Small Molecule

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OncologyPopPK

Imatinib Pharmacokinetics Guide

CML / GIST

Small Molecule

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Oncology1-CMT PopPK

Imbruvica (Ibrutinib) Pharmacokinetics Guide

Chronic lymphocytic leukemia

Small Molecule

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Oncology2-CMT PopPK

Imfinzi (Durvalumab) Pharmacokinetics Guide

Non-small cell lung cancer

mAb

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OncologyPopPK

Infigratinib Pharmacokinetics Guide

Cholangiocarcinoma

Small Molecule

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Oncology2-CMT PopPK

Keytruda (Pembrolizumab) Pharmacokinetics Guide

Melanoma and non-small cell lung cancer

mAb

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OncologypopPK

Keytruda Pharmacokinetics Guide

Cancer immunotherapy

PD-1 inhibitor

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Oncology1-CMT PopPK

Lynparza (Olaparib) Pharmacokinetics Guide

BRCA-mutated ovarian cancer

Small Molecule

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OncologypopPK

Methotrexate High-Dose Pharmacokinetics Guide

Cancer/RA

Antimetabolite

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OncologyPK/PD

Oncology Dose Selection Tool Pharmacokinetics Guide

Solid Tumors

Small Molecule

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Oncology2-CMT PopPK

Opdivo (Nivolumab) Pharmacokinetics Guide

Melanoma and non-small cell lung cancer

mAb

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OncologyPBPK-PD Model

PBPK-PD Topo1-Based ADC Pharmacokinetics Guide

Solid tumors (breast, lung, gastric, colorectal cancer)

Antibody-Drug Conjugate (ADC)

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OncologyPBPK-PD

PBPK-PD Topo1-Based ADC Pharmacokinetics Guide

Solid tumors (HER2-positive and Trop-2-positive cancers)

Antibody-Drug Conjugate

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OncologyPBPK-PD Model

PBPK-PD Topo1-Based ADC Pharmacokinetics Guide

Solid tumors (breast, lung, gastric, colorectal cancer)

Antibody-Drug Conjugate (ADC)

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Oncology

PBPK-PD of ADCs Pharmacokinetics Guide

Antibody-Drug Conjugate (ADC)

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OncologypopPK

Paclitaxel Pharmacokinetics Guide

Cancer chemotherapy

Taxane

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Oncology2-CMT PopPK

Perjeta (Pertuzumab) Pharmacokinetics Guide

HER2-positive breast cancer

mAb

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Oncology1-CMT PopPK

Pomalyst (Pomalidomide) Pharmacokinetics Guide

Multiple myeloma

Small Molecule

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Oncology

PopPK of Docetaxel Pharmacokinetics Guide

Taxane (Microtubule Stabilizer)

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Oncology1-CMT PopPK

Revlimid (Lenalidomide) Pharmacokinetics Guide

Multiple myeloma

Small Molecule

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OncologySemi-mechanistic PK/PD

Ruc Pharmacokinetics Guide

BRCA-mutant and HRD+ breast cancer

PARP inhibitor

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OncologyPK/PD

T-cell Engager Pharmacokinetics Guide

Hematologic Malignancies

mAb

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OncologyMinimal PBPK-TMDD with Target Shedding

TMDD Model Pharmacokinetics Guide

HER2-positive Breast Cancer

Monoclonal Antibody (Anti-HER2)

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Oncology1-CMT PopPK

Tagrisso (Osimertinib) Pharmacokinetics Guide

EGFR-mutated non-small cell lung cancer

Small Molecule

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Oncology2-CMT PopPK

Tecentriq (Atezolizumab) Pharmacokinetics Guide

Non-small cell lung cancer

mAb

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OncologyMinimal PBPK-TMDD

Trastuzumab (Herceptin) PBPK-TMDD Pharmacokinetics Guide

HER2-positive breast cancer

Anti-HER2 Monoclonal Antibody

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OncologyPopPK

Trastuzumab Pharmacokinetics Guide

HER2+ Breast Cancer

mAb

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OncologyPopPK

Trastuzumab Pharmacokinetics Guide

HER2+ Breast Cancer

mAb

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Oncology

Trastuzumab Pharmacokinetics Guide

Monoclonal Antibody

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OncologyPopulation PK (Triple-analyte: ADC + SN-38 payload + total antibody)

Trodelvy Pharmacokinetics Guide

Unresectable locally advanced or metastatic triple-negative breast cancer (mTNBC), HR+/HER2-negative metastatic breast cancer after endocrine and CDK4/6 inhibitor therapy, and locally advanced or metastatic urothelial cancer; TROP2-directed ADC with SN-38 payload

Antibody-Drug Conjugate (ADC)

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OncologyPK/PD

Tumor Exposure Analysis Model Pharmacokinetics Guide

Solid Tumors

mAb

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Oncology1-CMT PopPK

Verzenio (Abemaciclib) Pharmacokinetics Guide

HR+/HER2- metastatic breast cancer

Small Molecule

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Oncology1-CMT PopPK

Xtandi (Enzalutamide) Pharmacokinetics Guide

Metastatic castration-resistant prostate cancer

Small Molecule

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Oncology

capecitabine Pharmacokinetics Guide

Fluoropyrimidine / Oral Prodrug

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OncologyPopulation PK

lenvatinib_Gupta_26879594 Pharmacokinetics Guide

Advanced renal cell carcinoma, hepatocellular carcinoma, differentiated thyroid cancer

Multikinase Inhibitor (TKI)

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OncologyPopPK (2-compartment)

rucaparib ok model Pharmacokinetics Guide

Ovarian cancer, metastatic castration-resistant prostate cancer (mCRPC)

PARP Inhibitor

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OncologyPopulation PK/PD

rucaparib Pharmacokinetics Guide

BRCA-mutated advanced ovarian, fallopian tube, or primary peritoneal cancer

PARP Inhibitor

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